Scientists at the University of Minnesota have discovered that the natural testosterone boosters they tested work by boosting the levels of a hormone that helps your body absorb and use testosterone.
The team says the research is the first to demonstrate that these natural testosterone products, known as natural testosterone reuptake inhibitors, work by helping to boost the levels in animals.
The findings were published online in the journal Scientific Reports.
“It’s a very promising approach to improving the human health in terms of testosterone levels,” said study lead author Annette L. Koehler, an associate professor of biomedical sciences and biophysics at the university’s College of Veterinary Medicine.
“There’s a lot of work to be done in terms, not only how to use these products but how to make them safe and effective.”
Natural testosterone boosters were first discovered by researchers at the Mayo Clinic in the 1950s.
Now, the FDA has approved the products for use in men over the age of 40.
But since they can be expensive, the natural products have become less widely available.
To test the effectiveness of the natural boosters, the researchers at Mayo found that rats who received testosterone injections daily had higher levels of the hormone in their bloodstreams than those who received injections only once a week.
Researchers also found that testosterone levels increased in rats who had been given the testosterone boosters only once every six weeks.
The researchers also tested rats that received either the injectable or injectable and non-injectable testosterone boosters.
When given the injectables, the rats had higher testosterone levels and a higher rate of testosterone absorption in their blood.
The non-stimulated rats had lower testosterone levels but no difference in testosterone absorption.
“There’s been no previous study that shows that testosterone boosters work by increasing testosterone in the blood of animals,” Koehner said.
“We found that this was true for all of the animals we tested.”
The researchers say that this is the most convincing evidence that natural testosterone supplements work by improving the levels or absorption of testosterone in humans.
“These results are a tremendous achievement for our lab and are a milestone in the development of this promising natural testosterone therapy,” said co-author Jason L. Sacks, a professor of pharmacology and physiology at Mayo.
The research team hopes to continue to test these natural products in other animals, but says that the current studies show that they can also work in humans, with rats and mice.
The team is now looking to extend the study to test the impact of the injectibles and injectables in human adults.
“We’ve got to continue this work to understand whether the benefits we see in rats and humans are mediated through testosterone or other hormones, and if so, what the mechanism is,” Kuehler said.
The study was funded by the National Institutes of Health and the Mayo Research Foundation.